The Cardinals are excited about what the DeAndre Hopkins addition will mean for their offense around rising star quarterback Kyler Murray, and they should expect to win many more games than they did last year. But even with Jordan Love in the picture, as long as Aaron Rodgers is playing quarterback, Green Bay's offense will be a problem for opposing teams.

ET, NBC) (O/U: 51.5), Pittsburgh (-6) at New York Giants (7:15 p.m. This one will be as close as the odds suggest. Additionally, Drew Brees has typically started strong. Detroit is simply focused on the return of its own QB and what that will do for an offense that was making strides before he got hurt last season. The disrespect card should work, at least for Week 1.,,,,,

ET, Fox) (O/U: 43), Green Bay at Minnesota (-2.5) (1 p.m.

(Getty Images) However, in those head-to-head clashes, San Francisco thrived through the air with 718 passing yards. The last QB picked first overall to win his debut is none other than my colleague David Carr, who did it back in 2002.

ET on FOX), Indianapolis Colts at Jacksonville Jaguars (1 p.m. ET on FOX), Las Vegas Raiders at Carolina Panthers (1 p.m. This team flirted with the playoffs last year on the strength of an underrated defense despite seemingly endless turnovers from former passer Jameis Winston. The Chiefs lost almost nothing from their Super Bowl-winning roster, and while the Texans remain competive on the strength of Deshaun Watson's brilliance, they still don't stack up. The primary receiver on the other end of the matchup, Michael Thomas, has had some of his best games versus the Buccaneers. Will Baker Mayfield and the Browns continue to roll? Can the Cowboys' D rebound? ET, CBS) (Over/Under: 47.5), Indianapolis (-8.5) at Jacksonville (1 p.m. Other overs may be tougher to achieve because of the list of injuries affecting Super Bowl contenders at certain positions. Nate Burleson: Since 2003, quarterbacks selected No.

ET, Fox) (O/U: 48), Arizona at San Francisco (-6.5) (4:25 p.m. Rivers is also out to prove something to himself and others.

Any upsets on the horizon? I like the Panthers' offense to strike big in this game against a newly constructed defense, and for Rhule to win his first game as an NFL head coach. If the Saints flex their offensive muscle inside the Superdome, the NFC South showdown may easily eclipse the over/under of 48 assigned to the matchup.

It's a long road trip for an early kickoff, but at least Seattle has the cushion of the offseason rather than having to deal with such a challenge in the middle of their schedule. A year ago, Arizona allowed the ninth-most rushing yards in the NFL, but it did hold the 49ers to 135 yards on the ground in two meetings. Philip Rivers now lives in Florida, not too far from where he will make his debut as the Colts' new quarterback.

Plus, San Francisco and Baltimore suffer early losses to division rivals.

Regardless, Dallas is the more loaded team. The San Francisco 49ers are dealing with two injuries to their wide receiver corps. Scott Pioli: Philip Rivers is going to have an explosive debut for the Indianapolis Colts and throw for over 350 yards and three TDs. The Bears recently announced Mitchell Trubisky won the starting quarterback job over Nick Foles, which probably matters very little to their Week 1 opponent. ET on FOX), Tampa Bay Buccaneers at New Orleans Saints (4:25 p.m. NFL Network analysts make bold predictions for Week 8 of the 2020 NFL season. The Jets, meanwhile, are not yet ready to contend. NFL Network analysts give their bold predictions for Week 4 of the 2020 NFL season. Tom Brady's first game in a Tampa Bay Buccaneers uniform could the highest-scoring affair of Week 1. ET on CBS), Cleveland Browns at Baltimore Ravens (1 p.m. New England hasn't had much time to integrate the QB who was signed just before training camp, which would be an issue for anybody but Bill Belichick and Josh McDaniels. ET, Fox) (O/U: 49), Los Angeles Chargers (-3) at Cincinnati (4:05 p.m. Deebo Samuel was declared out for the opener against the Arizona Cardinals, and rookie Brandon Aiyuk is questionable, per Schefter. The Buccaneers hype is real, and for good reason. Will Khalil Mack break out of his slump? ET on CBS), Seattle Seahawks at Atlanta Falcons (1 p.m. (Getty Images) Which record will Russell Wilson break this week? ET, ESPN) (O/U: 46), Tennessee (-2.5) at Denver (10:10 p.m.

NFL Network analysts make bold predictions for Week 7 of the 2020 NFL season.

With a handful of trends going in the over's direction and Brady looking to impress in his first game out of New England, the over seems to be the safe bet as long as it stays beneath 50. Many were bothered by how the Packers handled their roster in the offseason. All other NFL-related trademarks are trademarks of the National Football League. Newly paid All-Pro DeAndre Hopkins starts earning his loot immediately by catching two of Murray's TDs while finishing with more than 100 yards receiving. ET, Fox) (O/U: 48), Dallas (-2.5) at Los Angeles Rams (8:20 p.m. Even with Winston throwing four interceptions in Week 11, the Saints and Bucs combined to put up 51 points. This game is the perfect opportunity for the Browns to prove themselves worthy of the optimism. We can't blame them, because even though their run to last season's AFC championship game came with a series of upsets, they're a legitimately solid team and much more proven than the Broncos. New Orleans had one of the most explosive offensive units in 2019, which was led by Brees and Michael Thomas. If he receives help from the secondary, the Cardinals could slow down quarterback Jimmy Garoppolo's top aerial threat. Brian Baldinger: When the Las Vegas Raiders visit the Carolina Panthers on Sunday, they will see a first-time head coach in Matt Rhule. In six meetings with New Orleans, the Tampa Bay receiver has a pair of 100-yard performances and four with 50 yards or fewer.

However, team travel for away games during the coronavirus pandemic is extra stressful, so the teams scheduled to make lengthy trips in Week 1 will be the first to deal with the NFL's extensive health and safety protocols for teams on the road. If Evans can't play, Godwin would likely receive the bulk of the primary targets from Brady, and that would give the wideout a chance to improve his form against the Saints. The six-time Super Bowl winner threw for three touchdowns in a trio of those contests, and he could be poised to record a similar total Sunday with Chris Godwin, Rob Gronkowski and O.J.

NFL Network analysts make bold predictions for Week 5 of the 2020 NFL season. Can the Houston Texans knock off the unbeaten Tennessee Titans? The Titans are probably looking at this line and playing the disrespect card even though they're opening the season on the road in a weird time slot. If the balance shifts back to the ground game, Kyle Shanahan's team could put up larger numbers on the ground. Paul Guenther is asked again to coordinate a Raiders defense that has a bunch of new faces for the third year in a row.

ET on ESPN), Tennessee Titans at Denver Broncos (10:20 p.m. Marc Ross: Kyler Murray stakes an early claim in the MVP race by leading the Cardinals to the biggest upset of the week in a win over San Francisco.

Get the latest NFL Week 1 picks from CBS Sports. That's as speedy a group of playmakers as you'll find in the NFL. He's been reunited with offensive coordinator Joe Brady, who was an assistant on New Orleans' staff during Bridgewater's first season with the Saints, and he'll be taking the field with Christian McCaffrey, Curtis Samuel, D.J. James Jones: It's been a long time since we've seen SuperCam on a football field. Las Vegas could have as many as five new starters on that side of the ball, including last year's first-round draft pick, Johnathan Abram, who missed all but one game in 2019. The health of the 49ers' top two receivers will affect how both teams finalize their game plans for Sunday's clash at Levi's Stadium.

Can James Conner steal the spotlight from Derrick Henry in the battle of unbeatens? That might not matter in Week 1, though, when the 49ers are so thin at wide receiver. Can Tom Brady and the Bucs rebound? Statistics obtained from Pro Football Reference.

Joe Burrow ends the streak on Sunday, picking up right where he left off in his college career, and leads the Cincinnati Bengals to a victory at home over the Los Angeles Chargers.

This would be a lot more fun if Tua Tagovailoa were starting over Ryan Fitzpatrick for the Dolphins, but we'll take what we can get with Cam Newton starting for the Patriots in their first post-Tom Brady era game. Now we're picking NFL games to open a season defined by changes amid the COVID-19 pandemic. Featured Columnist September 12, 2020 Comments. Howard at his disposal. This is a tough spot for the Seahawks, the team we like to win the NFC this season. Tampa Bay and New Orleans easily surpassed 48 points in their pair of meetings in 2019, and that was with Jameis Winston under center for the Buccaneers. Per tradition, the Week 1 NFL schedule begins with the defending Super Bowl champions — this year the Chiefs — hosting the Thursday night season-opener, and it ends with a "Monday Night Football" doubleheader.

He makes his New England debut memorable with five touchdowns -- two rushing, three passing -- against the Dolphins and has Patriots fans feeling as if the dynasty (albeit without Tom Brady) isn't quite over just yet. Washington has been fortunate to have new coach Ron Rivera guide the team through a turbulent offseason, but he won't be able to steer his players to many wins in 2020. How will Pats QB Cam Newton fare in his return?

(Getty Images) ET, Fox) (O/U: 45), Philadelphia (-5.5) at Washington (1 p.m.

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